As I posted about earlier the web 2.0 applications are forerunners to a new type of game development market that is opening up online. Namely online games of which the flash games are currently most famous and seems to be the default platform in the foreseeable future.
Two large companies are apparently aware of this development as Ubisoft and Garage games have both already started delivering for the platform. While Garage games game platform is a closed network that relies on a plugin download they already have advanced 3D games up and running. Visit InstantAction and have a look.
Ubisofts upcoming Heroes of Might and Magic: Kingdoms might be delivered through flash, but it is to early to tell will HOMMK.
Time will tell but if I were a large publishing house today I'd try like hell to push Adobe to release open GL or direct X support with flash.
Read the previous post for more on the point.